In regards to the Columbian Exchange , what was the major factor that killed majority of the Native Americans?

The major factor that led to the deaths of a significant number of Native Americans during the Columbian Exchange was the introduction of diseases, particularly smallpox, measles, influenza, and typhus, which were previously unknown to the indigenous populations of the Americas. These diseases spread rapidly among Native American communities, causing widespread devastation due to their lack of immunity and limited medical resources.