noisome noi-suhm adjective more noisome most noisome 1. having a very unpleasant smell : Skunks spray a noisome mist when they are threatened.2. harmful to health:A noisome secretion on a toad's skin can kill predators on contact.- from Middle English Which sentence uses the word noisome correctly? The McClains welcomed the new year with a noisome celebration. The Environmental Protection Agency warns against pouring noisome chemicals down the drain.